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Anti-inflammatory agent 36

CAS No. 2293951-01-4

Anti-inflammatory agent 36( —— )

Catalog No. M35803 CAS No. 2293951-01-4

Anti-inflammatory agent 36 is an anti-inflammatory agent that exhibited dose-dependent inhibition of LPS-induced release of TNF-a and IL-6 in active RAW 264.7 mouse macrophages (IC50 = 3.69 μM and 3.68 μM, respectively).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Anti-inflammatory agent 36
  • Note
    Research use only, not for human use.
  • Brief Description
    Anti-inflammatory agent 36 is an anti-inflammatory agent that exhibited dose-dependent inhibition of LPS-induced release of TNF-a and IL-6 in active RAW 264.7 mouse macrophages (IC50 = 3.69 μM and 3.68 μM, respectively).
  • Description
    Anti-inflammatory agent 36 is an anti-inflammatory agent. Anti-inflammatory agent 36 inhibits LPS-induced macrophage activation.
  • In Vitro
    Western Blot Analysis Cell Line:RAW 264.7 mouse macrophages Concentration:10 μM Incubation Time:0.5 h Result:Markedly inhibited P-P38 and P-ERK, indicating the suppression of MAPK signaling.
  • In Vivo
    Animal Model:Acute lung injury mouse model Dosage:10 mg/kg Administration:i.p.Result:Reduced wet/dry weight ratio of the mice lungs.Reduced biomarkers of lymphocytes and macrophages.Suppresses TNF-α, IL-6, IL-1β, 7 VACM-1 and ICAM-1 level.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Immunology/Inflammation related
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2293951-01-4
  • Formula Weight
    453.48
  • Molecular Formula
    C25H27NO7
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 25 mg/mL (55.13 mM; Ultrasonic (<60°C)
  • SMILES
    COc1cc(\C=C\C(=O)N2CCC\C(=C/c3cc(OC)c(OC)c(OC)c3)C2=O)ccc1O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Qian J, et al. Design and synthesis novel di-carbonyl analogs of curcumin (DACs) act as potent anti-inflammatory agents against LPS-induced acute lung injury (ALI). Eur J Med Chem. 2019 Apr 1;167:414-425. ?
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